Promethazine Hydrochloride 10mg – 56 Tablets

Description

Promethazine Hydrochloride 10mg – 56 Tablets

Promethazine Hydrochloride 10mg tablets are an antihistamine medicine used to relieve allergic conditions such as hay fever, allergic rhinitis, and skin reactions, as well as to prevent and treat travel (motion) sickness, and to provide short-term relief of sleep difficulties.

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How It Works

Promethazine works by blocking histamine receptors in the body. Histamine is a natural chemical released during allergic reactions that causes symptoms such as sneezing, itching, and a runny nose. By blocking histamine, promethazine reduces these symptoms. It also acts on parts of the brain involved in nausea and sleep, which is why it helps with travel sickness and sleeplessness.

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Directions for Use

Dosage varies depending on the condition being treated. For allergies in adults and children aged 10 and over: 10mg to 20mg up to three times daily. For travel sickness in adults: 25mg taken the night before travel, or 25mg taken 1–2 hours before travel. For short-term insomnia in adults: 25mg taken at bedtime. Promethazine is not recommended for children under 2 years of age. Always read the patient information leaflet before use. If you are unsure about the correct dose, speak to your PillSorted pharmacist.

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Active Ingredients

• Promethazine hydrochloride 10mg per tablet

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Possible Side Effects

• Drowsiness or sedation
• Dizziness or impaired coordination
• Dry mouth, nose, or throat
• Blurred vision
• Constipation or difficulty passing urine
• Restlessness or confusion (particularly in elderly patients)
• Headache

If you experience any serious side effects, stop taking this medicine and seek medical advice immediately.

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Who Should Not Take This Medicine

• Children under 2 years of age
• People with a known allergy to promethazine or any other phenothiazines
• People with certain liver conditions
• People with a history of epilepsy or seizures (unless under medical supervision)
• People with closed-angle glaucoma
• People with an enlarged prostate or difficulty passing urine
• Those currently taking or who have recently taken monoamine oxidase inhibitors (MAOIs)

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Interactions

Promethazine can interact with a number of medicines, including other sedatives, sleeping tablets, anti-anxiety medicines, antidepressants (particularly MAOIs and tricyclics), antipsychotics, and medicines for epilepsy. It may also interact with antimuscarinics (e.g., medicines for bladder problems) and some pain relief medicines. Tell your PillSorted pharmacist or doctor about all medicines you are currently taking, including herbal remedies and supplements.

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Pregnancy and Breastfeeding

Promethazine should be used with caution during pregnancy, particularly in the first trimester and close to the time of delivery, as it may affect the newborn. It may pass into breast milk and could cause drowsiness in a breastfed baby. Speak to your doctor or PillSorted pharmacist before use if you are pregnant, trying to conceive, or breastfeeding.

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Alcohol

You should avoid drinking alcohol whilst taking promethazine. Alcohol can significantly increase the sedative effects of this medicine, making drowsiness much worse and potentially dangerous. This is especially important if you need to drive or operate machinery.

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Driving and Operating Machinery

Promethazine causes drowsiness and can significantly impair your ability to drive or use machinery. You should not drive, cycle, or operate machinery whilst taking this medicine until you know how it affects you. The sedative effects can last into the following day, particularly when used as a sleep aid.

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Storage

Store below 25°C in a dry place, away from direct sunlight and moisture. Keep out of sight and reach of children. Do not use after the expiry date shown on the packaging.

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Important Information

• This product is a medicine. Speak to your doctor or PillSorted pharmacist before taking this product if you have an underlying medical condition or are taking any other medication or complementary therapy.
• If symptoms worsen or persist, contact your doctor.
• If pregnant, trying to conceive or breastfeeding, seek medical advice before use.
• If you suffer from allergies, confirm suitability with your PillSorted pharmacist before use.
• Store out of sight and reach of children.
• Read the enclosed patient information leaflet carefully before use.
• Contact your GP where appropriate.

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Patient Information Leaflet

For the full Patient Information Leaflet (PIL) for this medicine, visit the electronic Medicines Compendium (EMC). For further information about this medicine, visit NHS.uk.

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This content has been medically reviewed and approved by Zeinab Ardeshir (GPhC 2075730), Superintendent Pharmacist at PillSorted (GPhC-registered online pharmacy 9011258). Last reviewed: February 2026.