Bloating—a feeling of fullness or pressure in the abdomen—is a common side effect from GLP-1 injections. Treatments, such as semaglutide (Wegovy) and tirzepatide (Mounjaro), work in part by slowing down food leaving your stomach (known as gastric emptying), which can lead to trapped wind, bloating and stomach discomfort, especially in the early stages.
While it can be uncomfortable (and sometimes embarrassing), bloating from GLP-1 injections is usually temporary and manageable with a few simple strategies.
Common symptoms
- Abdominal distension or visible swelling
- Feeling uncomfortably full even after small meals
- Increased gas or flatulence
- Stomach discomfort or pressure
- Gurgling or rumbling sounds in the abdomen
How common is bloating with GLP-1 treatments?
Bloating varies by person, but studies show that about 40-70% of GLP-1-treated patients experience some form of gastrointestinal side effects, including nausea & vomiting, diarrhoea, constipation and abdominal pain. It is most common during the initial weeks of treatment and when dosages are increased. Most people’s symptoms improve after a few weeks as the body adjusts.
Managing bloating on GLP-1 treatments
Dietary adjustments
- Eat smaller, more frequent meals rather than three large meals
- Chew food thoroughly to aid digestion
- Limit carbonated beverages which can introduce more gas into your digestive system
- Stay well-hydrated but avoid drinking large volumes with meals
Lifestyle tips
- Take gentle walks after meals to encourage digestion
- Practise mindful eating by eating slowly and without distractions
- Maintain good posture whilst eating to reduce pressure on your stomach
- Keep a food diary to identify specific triggers for your bloating
Medical support
- Follow the prescribed dosing schedule carefully: rapid dose increases may worsen bloating
- Medications such as Gaviscon double-action, Wind-Setler, containing dimeticone, and Alka-Seltzer, may provide relief for some individuals
- Peppermint tea or peppermint oil capsules may also help relax the gut and reduce bloating
- Discuss with your clinician about temporarily slowing dose escalation if bloating is severe
When to seek medical advice
Contact your healthcare provider if you experience:
- Severe or worsening abdominal pain
- Bloating that does not improve after 2-3 weeks
- Significant distress or interference with daily activities
- Signs of a possible allergic reaction (rash, swelling of face/throat, difficulty breathing)
- Bloating accompanied by persistent vomiting or inability to keep fluids down
Long-term outlook
The majority of patients find that bloating eases within 4–8 weeks as their bodies get used to the medication. In the meantime, small changes to your routine can make a big difference in comfort and quality of life.
FAQs
Will bloating affect my weight loss results?
No, experiencing bloating does not diminish the effectiveness of your GLP-1 treatment. It’s simply a side effect of how the medication works.
Should I stop taking my medication if I experience bloating?
No, do not discontinue your medication without consulting your healthcare provider. Most bloating symptoms can be managed with the strategies outlined above.
Can probiotics help with GLP-1-related bloating?
Some patients report improvement with probiotic supplements, though clinical evidence is limited. Consult your healthcare provider before starting any supplements.
Is bloating worse with higher doses?
Bloating may temporarily worsen when dosages are increased, which is why GLP-1 treatments follow a gradual dose escalation schedule.
How can I tell the difference between normal bloating and a more serious issue?
Normal bloating is uncomfortable but not severely painful. It typically fluctuates throughout the day and responds to the management strategies above. Seek immediate medical attention if you experience intense pain, fever, or severe distension.
