Nytol Original 25mg – 20 Tablets
£5.69
In Stock
Nytol Original 25mg tablets are a short-term sleep aid used to relieve temporary sleeplessness and help you fall asleep more easily. They contain diphenhydramine hydrochloride, an antihistamine with well-established sedative properties.
Description
Nytol Original 25mg – 20 Tablets
Nytol Original 25mg tablets are a short-term sleep aid used to relieve temporary sleeplessness and help you fall asleep more easily. They contain diphenhydramine hydrochloride, an antihistamine with well-established sedative properties.
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How It Works
Diphenhydramine hydrochloride works by blocking histamine receptors in the brain, which produces a calming, drowsy effect. This helps you to fall asleep more quickly and enjoy a more restful night’s sleep.
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Directions for Use
Adults and young people aged 16 years and over should take 2 tablets (50mg) by mouth approximately 20 minutes before bedtime. Do not take more than 2 tablets in any 24-hour period, and do not use for more than 2 consecutive nights without seeking medical advice. This medicine is not suitable for children under 16 years of age. Always read the patient information leaflet before use. If you are unsure about the correct dose, speak to your PillSorted pharmacist.
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Active Ingredients
• Diphenhydramine hydrochloride 25mg per tablet
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Possible Side Effects
• Drowsiness or grogginess the following morning
• Dry mouth, nose, or throat
• Blurred vision
• Difficulty passing urine
• Nausea or upset stomach
• Headache
• Dizziness
If you experience any serious side effects, stop taking this medicine and seek medical advice immediately.
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Who Should Not Take This Medicine
• Children under 16 years of age
• Anyone with an allergy to diphenhydramine or any other ingredient in the tablet
• People with glaucoma (increased pressure in the eye)
• People with difficulty passing urine or an enlarged prostate
• Those with severe liver disease
• People with epilepsy or a history of seizures
• Individuals with certain breathing problems such as asthma or chronic obstructive pulmonary disease (COPD)
• People already taking other medicines that cause drowsiness, including sedatives or tranquillisers
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Interactions
Nytol Original may interact with other medicines that cause drowsiness, such as sleeping tablets, anxiety medicines, antidepressants, and certain antihistamines. It may also interact with monoamine oxidase inhibitors (MAOIs) and some medicines used to treat stomach problems. Tell your PillSorted pharmacist or doctor about all medicines you are currently taking, including herbal remedies and supplements.
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Pregnancy and Breastfeeding
Nytol Original is not recommended during pregnancy or whilst breastfeeding, as diphenhydramine may pass into breast milk and could affect your baby. Speak to your doctor or PillSorted pharmacist before use if you are pregnant, trying to conceive, or breastfeeding.
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Alcohol
You should not drink alcohol whilst taking Nytol Original. Alcohol increases the sedative effect of diphenhydramine, which can lead to excessive drowsiness and may be dangerous, particularly if you need to drive or operate machinery the following day.
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Driving and Operating Machinery
Nytol Original causes drowsiness, which may persist into the following morning. You should not drive, operate machinery, or perform any activity requiring full alertness until you are certain this effect has worn off completely. If in doubt, do not drive.
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Storage
Store below 25°C in a dry place, away from direct sunlight and moisture. Keep out of sight and reach of children. Do not use after the expiry date shown on the packaging.
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Important Information
• This product is a medicine. Speak to your doctor or PillSorted pharmacist before taking this product if you have an underlying medical condition or are taking any other medication or complementary therapy.
• If symptoms worsen or persist, contact your doctor.
• If pregnant, trying to conceive or breastfeeding, seek medical advice before use.
• If you suffer from allergies, confirm suitability with your PillSorted pharmacist before use.
• Store out of sight and reach of children.
• Read the enclosed patient information leaflet carefully before use.
• Contact your GP where appropriate.
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Patient Information Leaflet
For the full Patient Information Leaflet (PIL) for this medicine, visit the electronic Medicines Compendium (EMC). For further information about this medicine, visit NHS.uk.
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This content has been medically reviewed and approved by Zeinab Ardeshir (GPhC 2075730), Superintendent Pharmacist at PillSorted (GPhC-registered online pharmacy 9011258). Last reviewed: February 2026.
| Weight | 0.02 kg |
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| Dimensions | 8.4 × 6.4 × 1.9 cm |
| Brand | NYTOL |
