Clotrimazole 500mg Pessary With Applicator (Brand May Vary)

Description

Clotrimazole 500mg Pessary With Applicator (Brand May Vary)

Clotrimazole 500mg Pessary is a single-dose treatment for vaginal thrush (candidal vulvovaginitis). It contains clotrimazole, an antifungal medicine that kills the Candida yeast responsible for the infection. The pessary is inserted into the vagina using the applicator provided and works overnight.

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How It Works

Clotrimazole is an antifungal that works by damaging the cell membrane of the Candida fungus. It inhibits the production of ergosterol, a substance the fungus needs to maintain its cell membrane. Without ergosterol, the fungal cells become weakened and die, clearing the infection.

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Directions for Use

Insert one 500mg pessary into the vagina at bedtime using the applicator provided. The pessary should be inserted as high as comfortably possible. Use a single dose — one pessary is usually sufficient. If symptoms persist after 7 days or recur within 2 months, consult your doctor. Do not use tampons, intravaginal douches or spermicides during treatment. If you are unsure how to use this product, speak to your PillSorted pharmacist.

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Active Ingredients

• Clotrimazole 500mg per pessary

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Possible Side Effects

• Mild vaginal burning or irritation after insertion (common)
• Itching or discomfort (common)
• Abdominal pain or cramps (uncommon)
• Allergic reaction such as rash (rare)

If irritation is severe or symptoms worsen, stop using the product and speak to your doctor.

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Who Should Not Use This Product

• People with a known allergy to clotrimazole or any other ingredient
• Girls under 16 years of age (consult a doctor first)
• Women over 60 years of age (consult a doctor first)
• If this is the first time you have had thrush symptoms (consult a doctor for diagnosis first)
• If you have had more than 2 episodes of thrush in the last 6 months (consult a doctor)

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Interactions

Clotrimazole pessaries may damage latex condoms and diaphragms. Use alternative contraception for at least 5 days after treatment. Tell your PillSorted pharmacist or doctor about all medicines you are currently using.

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Pregnancy and Breastfeeding

Do not use clotrimazole pessaries during pregnancy without consulting your doctor first. If you are pregnant, your doctor may recommend treatment but advise against using the applicator — the pessary can be inserted by hand instead. Clotrimazole is generally considered safe during breastfeeding. Speak to your doctor or PillSorted pharmacist before use.

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Storage

Store below 25°C. Keep in the original packaging. Keep out of sight and reach of children. Do not use after the expiry date shown on the packaging.

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Important Information

• This product is a medicine. Speak to your doctor or PillSorted pharmacist before taking this product if you have an underlying medical condition or are taking any other medication or complementary therapy.
• If symptoms worsen or persist, contact your doctor.
• If pregnant, trying to conceive or breastfeeding, seek medical advice before use.
• If you suffer from allergies, confirm suitability with your PillSorted pharmacist before use.
• Store out of sight and reach of children.
• Read the enclosed patient information leaflet carefully before use.
• Contact your GP where appropriate.

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Patient Information Leaflet

For the full Patient Information Leaflet (PIL) for this product, visit the electronic Medicines Compendium (EMC). For further information about thrush, visit NHS.uk.

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This content has been medically reviewed and approved by Zeinab Ardeshir (GPhC 2075730), Superintendent Pharmacist at PillSorted (GPhC-registered online pharmacy 9011258). Last reviewed: March 2026.