Headaches from GLP-1 injections, such as semaglutide (Wegovy) and tirzepatide (Mounjaro), are not as widely discussed as nausea or bloating. Yet, they are a recognised side effect, especially in the early stages or during dose increases. These medications affect multiple systems in the body, including hydration levels, blood sugar regulation, and digestion, all of which can contribute to the onset of headaches.
Understanding the causes and implementing targeted management approaches can help you maintain your treatment goals whilst minimising discomfort. This comprehensive guide provides practical solutions to help you navigate headaches confidently during your health journey.
Common symptoms
- Dull or throbbing head pain
- Tension around the temples, forehead, or back of the head
- Sensitivity to light or sound
- Nausea or fatigue accompanying the headache
- Headache triggered by hunger, dehydration, or low blood sugar
How common are headaches from GLP-1 treatments?
Headaches are a recognised but less common side effect of GLP-1 medications. Rates vary depending on the specific drug and dose, but studies show that around 10% of people taking semaglutide report headaches—most commonly during the first few weeks or after a dose increase. For tirzepatide, the incidence is slightly lower, ranging from 2.6% to 6.8%, depending on the dosage.
These headaches are usually mild and temporary, improving as your body adjusts to treatment.
Managing Headaches on GLP-1 treatments
Hydration and nutrition
- Drink consistently throughout the day – aim for at least 2 litres of water
- Avoid skipping meals, especially if your appetite is reduced
- Include slow-release carbohydrates and protein in meals to help stabilise blood sugar
- Limit caffeine and alcohol, which can both trigger or worsen headaches
Lifestyle tips
- Get enough sleep, poor rest can trigger headaches and worsen fatigue
- Practise stress-reducing techniques like deep breathing or short walks
- Create a calm, dark space if you feel a headache coming on
- Track potential triggers such as dehydration, screen time, or missed meals
Medical support
- Follow your dosing schedule carefully – rapid dose increases may increase headache frequency
- Over-the-counter pain relief such as paracetamol or ibuprofen may help (check with your pharmacist)
- Magnesium supplements may be helpful for some, though evidence is mixed—discuss with your GP
- If headaches persist, speak to your healthcare provider about adjusting your treatment plan
When to seek medical advice
Contact your GP or pharmacist if you experience:
- Headaches that are severe, worsening, or daily
- Headaches that interfere with work, sleep, or daily activities
- Signs of dehydration (dark urine, dry mouth, dizziness)
- New visual symptoms such as blurred vision or flashing lights
- Headaches accompanied by vomiting, fever, or stiff neck
Seek urgent care if you experience:
- Sudden, severe “thunderclap” headache
- Headache following a head injury
- Difficulty speaking, confusion, or weakness
- Any signs of a possible stroke
Long-term outlook
Most headaches related to GLP-1 treatment ease within a few weeks, especially with consistent hydration, balanced meals, and proper rest. Identifying your personal triggers can help you stay ahead of symptoms and maintain energy and focus throughout your treatment journey.
FAQs
Are headaches a common side effect of GLP-1 injections?
They’re not the most common side effect, but they do affect around 5–15% of people, especially early on or during dose increases.
Can dehydration cause headaches on GLP-1s?
Yes. Reduced appetite can lead to lower fluid intake. Staying hydrated is key to preventing headache symptoms.
Do headaches mean I should stop treatment?
Not necessarily. Most cases are mild and improve with time. Speak to your pharmacist or GP before making any changes to your treatment.
Are headaches linked to low blood sugar?
Possibly. If you’re eating significantly less, your blood sugar may drop, which can lead to fatigue or headaches. Try eating small, balanced meals regularly.
Can I take pain relief for headaches on GLP-1s?
Yes, paracetamol is generally safe. Always check with a pharmacist before using any new medications or supplements regularly.
