Nytol One-A-Night 50mg – 20 Tablets

Description

Nytol One-A-Night 50mg – 20 Tablets

Nytol One-A-Night 50mg tablets are a short-term sleep aid used to relieve occasional sleeplessness and help you get a restful night’s sleep. They contain diphenhydramine hydrochloride, an antihistamine with well-known sedative properties.

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How It Works

Diphenhydramine hydrochloride works by blocking histamine receptors in the brain, which produces a calming, drowsy effect. This helps you fall asleep more easily when you are experiencing temporary difficulty sleeping. It is intended for short-term use only and is not suitable as a long-term solution for insomnia.

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Directions for Use

Adults aged 16 years and over should take one tablet (50mg) approximately 20 minutes before going to bed. Swallow the tablet whole with water. Do not take more than one tablet in 24 hours, and do not use for more than two consecutive weeks without speaking to a doctor. Always read the patient information leaflet before use. If you are unsure about the correct dose, speak to your PillSorted pharmacist.

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Active Ingredients

• Diphenhydramine hydrochloride 50mg per tablet

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Possible Side Effects

• Drowsiness or sedation the following day
• Dry mouth, nose, or throat
• Blurred vision
• Difficulty urinating
• Constipation
• Dizziness or difficulty concentrating
• Nausea or upset stomach

If you experience any serious side effects, stop taking this medicine and seek medical advice immediately.

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Who Should Not Take This Medicine

• Children under 16 years of age
• People with an enlarged prostate or difficulty passing urine
• People with glaucoma (raised pressure in the eye)
• People with epilepsy
• People with chronic respiratory conditions such as asthma or chronic obstructive pulmonary disease (COPD)
• People with porphyria (a rare metabolic disorder)
• Anyone who is allergic to diphenhydramine or any other ingredient in the product
• People taking monoamine oxidase inhibitors (MAOIs) or who have taken them within the past 14 days

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Interactions

Diphenhydramine can interact with a number of medicines, including other sedatives, antidepressants, antipsychotics, antihistamines, and medicines for anxiety or epilepsy — potentially increasing drowsiness or other side effects. It may also interact with medicines used for stomach problems (such as metoclopramide) or certain heart medicines. Tell your PillSorted pharmacist or doctor about all medicines you are currently taking, including herbal remedies and supplements.

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Pregnancy and Breastfeeding

Nytol One-A-Night is not recommended during pregnancy or whilst breastfeeding. Diphenhydramine may pass into breast milk and could affect your baby. Speak to your doctor or PillSorted pharmacist before use if you are pregnant, trying to conceive, or breastfeeding.

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Alcohol

You should not drink alcohol while taking Nytol One-A-Night 50mg. Alcohol can significantly increase the sedative effects of diphenhydramine, leading to excessive drowsiness and impairing your judgement and reactions. This combination can be dangerous, particularly if you need to drive or operate machinery the following day.

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Driving and Operating Machinery

Nytol One-A-Night causes drowsiness, which may continue into the following day. You should not drive, operate heavy machinery, or carry out tasks that require full alertness until you know how this medicine affects you. If you feel drowsy the morning after taking a tablet, do not drive or operate machinery.

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Storage

Store below 25°C in a dry place, away from direct sunlight and moisture. Keep out of sight and reach of children. Do not use after the expiry date shown on the packaging.

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Important Information

• This product is a medicine. Speak to your doctor or PillSorted pharmacist before taking this product if you have an underlying medical condition or are taking any other medication or complementary therapy.
• If symptoms worsen or persist, contact your doctor.
• If pregnant, trying to conceive or breastfeeding, seek medical advice before use.
• If you suffer from allergies, confirm suitability with your PillSorted pharmacist before use.
• Store out of sight and reach of children.
• Read the enclosed patient information leaflet carefully before use.
• Contact your GP where appropriate.

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Patient Information Leaflet

For the full Patient Information Leaflet (PIL) for this medicine, visit the electronic Medicines Compendium (EMC). For further information about this medicine, visit NHS.uk.

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This content has been medically reviewed and approved by Zeinab Ardeshir (GPhC 2075730), Superintendent Pharmacist at PillSorted (GPhC-registered online pharmacy 9011258). Last reviewed: February 2026.

Brand	NYTOL