Nurofen Plus (12.8mg/200mg) – 32 Tablets

Description

Nurofen Plus (12.8mg/200mg) – 32 Tablets

Nurofen Plus tablets provide dual-action pain relief, combining ibuprofen and codeine phosphate to treat moderate pain that has not responded to ibuprofen or paracetamol alone. They are suitable for adults and children aged 12 and over for conditions such as headache, dental pain, period pain, muscular aches, and cold or flu symptoms.

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How It Works

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that works by blocking the production of prostaglandins — chemicals in the body that cause pain, swelling, and inflammation. Codeine phosphate is an opioid painkiller that acts on pain receptors in the brain and spinal cord to reduce the feeling of pain. Together, these two ingredients target pain through different pathways, providing stronger relief than either ingredient alone.

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Directions for Use

Adults and children aged 12 and over: take 1–2 tablets up to three times a day as needed, leaving at least 4 hours between doses. Do not take more than 6 tablets in any 24-hour period. Swallow the tablets whole with a glass of water, preferably with or after food to reduce the chance of stomach upset. Do not use for more than 3 days without speaking to a doctor. This medicine is not suitable for children under 12 years of age. Always read the patient information leaflet before use. If you are unsure about the correct dose, speak to your PillSorted pharmacist.

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Active Ingredients

• Ibuprofen 200mg per tablet
• Codeine phosphate hemihydrate 12.8mg per tablet

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Possible Side Effects

• Nausea, vomiting, or stomach upset
• Constipation
• Drowsiness or dizziness
• Headache
• Indigestion or stomach pain
• Skin rash or itching
• In rare cases, stomach bleeding or ulcers

If you experience any serious side effects, stop taking this medicine and seek medical advice immediately.

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Who Should Not Take This Medicine

• Children under 12 years of age
• People who are allergic to ibuprofen, codeine, aspirin, or any other NSAID
• People with a current or history of stomach ulcers or gastrointestinal bleeding
• People with severe kidney, liver, or heart failure
• People who are known ultra-rapid metabolisers of codeine (a genetic condition)
• Breastfeeding mothers
• People with asthma that is triggered by NSAIDs
• Anyone who has had a previous allergic reaction to this medicine

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Interactions

Nurofen Plus may interact with other NSAIDs (such as aspirin), blood-thinning medicines (such as warfarin), antidepressants (including SSRIs and MAOIs), other opioid painkillers, medicines for high blood pressure, diuretics, lithium, and methotrexate. Taking codeine alongside other medicines that cause drowsiness — including sleeping tablets, antihistamines, or anti-anxiety medicines — may increase sedation. Tell your PillSorted pharmacist or doctor about all medicines you are currently taking, including herbal remedies and supplements.

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Pregnancy and Breastfeeding

Nurofen Plus should not be taken during pregnancy, particularly from 20 weeks onwards, as ibuprofen may harm the unborn baby. Codeine must not be used while breastfeeding, as it can pass into breast milk and cause serious harm to the baby. Speak to your doctor or PillSorted pharmacist before use if you are pregnant, trying to conceive, or breastfeeding.

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Alcohol

You should avoid drinking alcohol while taking Nurofen Plus. Alcohol increases the risk of stomach bleeding associated with ibuprofen, and it can enhance the sedative effects of codeine, making drowsiness and dizziness worse.

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Driving and Operating Machinery

Nurofen Plus contains codeine, which can cause drowsiness, dizziness, and impaired concentration. You should not drive, operate heavy machinery, or perform any activity requiring full alertness until you know how this medicine affects you. If you feel drowsy or unwell after taking this medicine, do not drive.

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Storage

Store below 25°C in a dry place, away from direct sunlight and heat. Keep out of sight and reach of children. Do not use after the expiry date shown on the packaging.

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Important Information

• This product is a medicine. Speak to your doctor or PillSorted pharmacist before taking this product if you have an underlying medical condition or are taking any other medication or complementary therapy.
• If symptoms worsen or persist, contact your doctor.
• If pregnant, trying to conceive or breastfeeding, seek medical advice before use.
• If you suffer from allergies, confirm suitability with your PillSorted pharmacist before use.
• Store out of sight and reach of children.
• Read the enclosed patient information leaflet carefully before use.
• Contact your GP where appropriate.

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Patient Information Leaflet

For the full Patient Information Leaflet (PIL) for this medicine, visit the electronic Medicines Compendium (EMC). For further information about this medicine, visit NHS.uk.

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This content has been medically reviewed and approved by Zeinab Ardeshir (GPhC 2075730), Superintendent Pharmacist at PillSorted (GPhC-registered online pharmacy 9011258). Last reviewed: February 2026.

Brand	Nurofen